Intravenous

Community-acquired pneumonia

Adult: 500 mg as single IV daily dose for at least 2 days followed by a single oral daily dose of 500 mg to complete 7-10 days of therapy. Elderly: No dosage adjustment needed.

Pelvic inflammatory disease

Adult: 500 mg as single IV daily dose for 1-2 days followed by a single oral daily dose of 250 mg tablet to complete a 7-day therapy. Elderly: No dosage adjustment needed.

Oral Skin and soft tissue infections, Respiratory tract infections

Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on the 1st day followed by 250 mg once daily for 4 days. Child: >6 mth 10 mg/kg; 15-25 kg: 200 mg; 26-35 kg: 300 mg; 36-45 kg: 400 mg. All doses to be taken once daily for 3 days. Elderly: No dosage adjustment needed.

Uncomplicated genital infections due to Chlamydia trachomatis, Chancroid, Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis

Adult: 1 g as a single dose. Elderly: No dosage adjustment needed.

Prophylaxis of disseminated Mycobacterium avium complex (MAC) infections

Adult: 1.2 g once wkly. For treatment or secondary prophylaxis: 500 mg once daily w/ other antimycobacterials. Child: 20 mg/kg once wkly. Max: 1.2 g. Alternatively 5 mg/kg once daily. Max: 250 mg. Elderly: No dosage adjustment needed.

Uncomplicated gonorrhoea

Adult: 2 g as a single dose. Elderly: No dosage adjustment needed.

Active immunisation against typhoid fever caused by Salmonella typhi

Adult: 1 g once daily for 5 days or 500 mg once daily for 7 days. Child: 3-17 yr 20 mg/kg (Max: 1 g) once daily for 5-7 days or 10 mg/kg (Max: 500 mg). Elderly: No dosage adjustment needed.

Granuloma inguinale

Adult: Initially, 1 g followed by 500 mg daily. Alternatively, 1 g once a wk for at least 3 wk, until all lesions have completely healed. Elderly: No dosage adjustment needed.