Imipenem and Cilastatin Sodium
FIOCILAS contains Imipenem + Cilastatin. The Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. Imipenem and cilastatin is a combination medicine used to treat severe infections of the lower respiratory tract, skin, stomach, or female reproductive organs
Adult: In terms of imipenem: A single 500 mg dose may be used.
Mild to moderate susceptible infections
Adult: In terms of imipenem, 500 mg or 750 mg every 12 hr.
Prophylaxis of surgical infections
Adult: In terms of imipenem, 1 g given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.
Adult: In terms of imipenem, 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 minutes, and doses of 750 mg or 1 g over 40-60 minutes. Child: >40 kg: same as adult dose. >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr.
FIOCILAS Powder for Injection I.V. 1 g
Each vial contains : Imipenem 500 mg and Cilastatin Sodium equivalent to Cilastatin 500 mg
Box, 1 vial @ 1 g