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Clopidogrel 75 mg

Clopidogrel bisulfate

Short Description

Clopidogrel Bisulfate containing Clopidogrel bisulfate (equivalent to Clopidogrel) is available in 75 mg film coated tablet.

Indications

Clopidogrel Bisulfate is indicated for the prevention of atherothrombotic events in :

  1. 1Patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial disease.

  2. Patients suffering from acute coronary syndrome :

  • Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction). In combination with Acetylsalicylic acid (ASA).

  • ST segment elevation acute myocardial infarction. In combination with ASA in medically treated patients eligible for thrombolytic therapy.

Specification

Adults and elderly :

Clopidogrel should be given as a single daily dose of 75 mg with or without food. In patients suffering from acute coronary syndrome :

  • Non-ST segment elevation (unstable angina or non-Q wave myocardial infarction) : Clopidogrel treatment should be initiated with a single 300 mg loading dose and then continued at 75 mg once a day (with acetylsalicylic acid (ASA) 75 - 325 mg daily). Since higher doses of ASA were associated with higher bleeding risk it is recommended that the dose of ASA should not be higher than 100 mg. The optimal duration of treatment has not been formally established. Clinical trial data support use up to 12 months, and the maximum benefit was seen at 3 months.

  • - ST segment elevation acute myocardial infarction : Clopidogrel should be given as a single daily dose of 75 mg initiated with or without a loading dose in combination with ASA and with or without thrombolytics. For patients greater than 75 years of age Clopidogrel should be initiated without a loading dose. Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks. The benefit of the combination of Clopidogrel with ASA beyond four weeks has not been studied in this setting.


Children and adolescents :

There is no experience in children.

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