Cefoperazone + Sulbactam Injection
Cefoperazone sodium and Sulbactam sodium
Short Description
Cefoperazone Sodium-Sulbactam Sodium containing Cefoperazone sodium (equivalent to Cefoperazone) and Sulbactam sodium (equivalent to Sulbactam) as active ingridients is available in 1 g of sterile powder for injection in vial pack.
Indications
Monotherapy : For the treatment of the following infections caused by sensitive organisms : respiratory tract infections (upper and lower), urinary tract infections (upper and lower) peritonitis, cholecystitis, cholangitis, and other intra abdominal infections, skin and soft tissue infections.
Combination therapy : because of the board spectrum of activity of Cefoperazone Sodium-Sulbactam Sodium may be used concomitantly with other antibioticss if such combination is indicated.
Specification
ADULTS
The recommended daily dose of Cefoperazone Sodium-Sulbactam Sodium for adults is as follows :
Ratio : 1:1
Cefoperazone Sodium-Sulbactam Sodium : 2-4 g
Sulbactam activity : 1-2 g
Cefoperazone activity 1-2 g
Dose should be administered every 12 hours in equally divided doses. In severe or refractory infections the daily dosage of Cefoperazone Sodium-Sulbactam Sodium may be increased up to 8 g of the 1:1 (i.e. 4 g Cefoperazone activity). Patients recieving the 1:1 ratio may require additional Cefoperazone administered seperately. Doses should be administered every 12 hours in equally divided doses. The recommended maximum daily dosage of Sulbactam is 4 g.
RENAL DYSFUNCTION
Dosage regimens of Cefoperazone Sodium-Sulbactam Sodium should be adjusted in patients with marked decrease in renal function (creatinine clearance < 30 ml/minute) to compensate for the reduced clearance of Sulbactam. Patients with creatinine clearance of 15-30 ml/minute should recieved a maximum of 1 g of Sulbactam administered every 12 hours (maximum daily dosage of 2 g Sulbactam), while patients with creatinine clearance < 15 ml/minute should receive a maximum of 500 mg of Sulbactam every 12 hours (maximum daily dosage of 1 g Sulbactam). In severe infections it may be necessary to administer additional Cefoperazone. The pharmacokinetic profile to Sulbactam is significantly altered by hemodialysis. The serum half-life of Cefoperazone is reduced slightly during hemodialysis. Thus, dosing should be scheduled to follow a dialysis period.
CHILDREN
Ratio : 1:1
Cefoperazone Sodium-Sulbactam Sodium (mg/kg/day) : 40-80 g
Sulbactam activity (mg/kg/day): 20-40 g
Cefoperazone activity (mg/kg/day) : 20-40 g
Doses should be administered every 6-12 hours in equally divided doses. In serious or refractory infections, these dosages may be increased up to 160 mg/kg/day of the 1:1 ratio. Doses should be administered in 2-4 equally divided doses.
NEONATES
For neonates in the first week of life, Cefoperazone Sodium-Sulbactam Sodium should be given every 12 hours. The maximum daily dosage of Sulbactam in pediatrics should not exceed 80 mg/kg/day. For doses of Cefoperazone Sodium-Sulbactam Sodium requiring > 80 mg/kg/day Cefoperazone activity, additional Cefoperazone should be administered separately.
