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Cefadroxil Monohydrate 500 mg

Cefadroxil Monohydrate

Short Description

Cefadroxil monohydrate with Cefadroxil monohydrate (equivalent tot Cefadroxil anhydrate) as active ingredients is available in 500 mg capsule.

Indications

Cefadroxil monohydrate is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases :

  • Respiratory tract infections caused by Streptococcus pyogenes (Group A B-hemolytic streptococci).

  • Skin and soft tissue infections caused by staphylococci and/or streptococci.

  • Urinary tract infections caused by E. coli, P. mirabilis, and Klesbsiella sp.

  • Other infections : Osteomyelitis and septic arthritis.

Specification

Adults :

  • Respiratory tract infections :

  • For mild infections : 1 g per day in 2 divided doses (500 mg, 2 times a day)

  • Moderate to severe infections : 1-2 g daily in 2 divided doses (500 mg - 1 g every 12 hours).

  • Pharyngitis and tonsillitis due to group A B-hemolytic streptococci : 1 g per day in single or divided doses (500 mg 2 times a day) for at least 10 days

  • Skin and soft tissue infections (i.e. cystitis) : 1-2 g per day in single or divided doses (2 times a day).

  • For all other urinary tract infections : 2 g per day in divided doses (2 times a day).


In the treatment of B-hemolytic streptococcal infections : A therapeutic dosage of Cefadroxil should be administered for at least 10 days.

For the treatment of B--hemolytic streptococcal pharyngitis or tonsillitis in both adults and children : Cefadroxil may be administered in the usual dose either in divided (2 times a day) or single doses.

In patients with renal impairment :  The dosage of Cefadroxil should be adjusted according to creatinine clearance rates to prevent drug accumulation. In adults, the initial dose is 1000 mg of Cefadroxil and the maintenance dose (based on the creatinine clearance rate [ml/minute/1.73 m2]) ]) is 500 mg at the time intervals listed below :

  • 0-10 ml/min : 36 hours

  • 10-25 ml/min : 24 hours

  • 25-50 ml/min : 12 hours

  • >50ml/min : Normal dosage

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