Amlodipine Besilate 5 mg
Amlodipine Besilate containing Amlodipine besilate (equivalent to Amlodipine) as active ingridient is available in caplet 5 mg and 10 mg.
The first line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority patients. Patients not adequately controlled on a single antihypertensive agent (other than Amlodipine) may benefit from the addition of Amlodipine, which has been used in combination with a Thiazide diuretic, B-adrenoceptor blocking agent, or an angiotensin-converting enzyme inhibitor.
The first line treatment of myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm/vasoconstriction (Prinzmetals or variant angina) of coronary vasculature. Amlodipine may be used where the clinical presentation suggest a possible vasospastic/vasoconstrictive component but where vasopastic/vasoconstrictive has not been confirmed. Amlodipine may be used alone, as monotherapy, or in combination with other antiangina drugs in patients with angina that is refractory to Nirates and/or adequate doses of B-blockers.
For hypertension : The usual initial dose is 5 mg Amlodipine once daily which may be increased to a maximum dose of 10 mg, depending on the individual patients response and severity. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Amlodipine to other antihypertensive therapy.
Majority of hypertensive patients with 5 mg/day the dose may not necessarily be increased. For those who need higher dose, Amlodipine can be increased to 7.5 mg/day with maximum dose of 10 mg/day.
The recommended dose for chronic stable or vasopastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.
No dose adjustment of Amlodipine is required upon concomitant administration of Thiazide diuretics, B-blockers, and angiotensin-converting enzyme inhibitors.
Use in children : No experience is available on use of Amlodipine in children.