Parenteral

Nausea and vomiting associated with cancer chemotherapy

Adult: Highly emetogenic chemotherapy: 8 mg as a single dose, given IM or slow IV inj immediately prior to treatment; or 8 mg IM or slow IV inj given immediately prior to treatment followed by either continuous IV infusion of 1 mg/hr for up to 24 hr or by a further 2 doses of 8 mg 2-4 hr apart; or 32 mg as a single dose via IV infusion over ≥15 min immediately prior to treatment; or 150 mcg/kg IV infusion over 15 min (beginning 30 min prior to chemotherapy) and repeated 4 and 8 hr after the 1st dose. Anti-emetic efficacy can be enhanced by giving dexamethasone sodium phosphate 20 mg IV prior to chemotherapy. Child: ≥6 mth 150 mcg/kg via IV infusion 30 min prior to the start of chemotherapy, repeat dose at 4 and 8 hr after the initial dose. Elderly: No dosage adjustment needed.

Treatment and prophylaxis of postoperative nausea and vomiting

Adult: 4 mg as a single dose via IM or 4-8 mg slow IV inj at induction of anaesth. Child: ≥1 mth 100 mcg/kg by slow IV inj. Max: 4 mg. Elderly: No dosage adjustment needed.